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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sa, Jin-yu | SP | Boston Beaneaters | 17 | 07/16/2017 | Chongju | KOR | Right | Right | 6' 2" | 175 lbs | - |
| Saggers, Edward | CF | Philadelphia Quakers | 22 | 06/20/2012 | Columbia | USA | Right | Right | 6' 4" | 200 lbs | $300,000 |
| Saikawa, Tsukasa | C | Hollywood Stars | 17 | 12/10/2017 | Owariashi | JPN | Switch | Right | 6' 1" | 185 lbs | - |
| Salazar, Jesús | SP | Hollywood Stars | 27 | 03/03/2007 | Malvern | USA | Right | Right | 6' 2" | 210 lbs | $1,220,000 |
| Salazar, Manuel | 1B | Brooklyn Superbas | 17 | 03/12/2017 | Santo Domingo | DOM | Right | Right | 6' 5" | 220 lbs | - |
| Salinas, Roberto | LF | Hollywood Stars | 31 | 03/09/2003 | Unknown | MEX | Left | Left | 5' 10" | 200 lbs | $22,400,000 |
| Sánchez, Carlos | SP | Hollywood Stars | 16 | 03/07/2018 | Bayamón | PUR | Right | Right | 5' 10" | 155 lbs | - |
| Sánchez, Harry | CF | Free Agent | 30 | 02/19/2004 | Brooklyn | USA | Right | Right | 6' 2" | 210 lbs | - |
| Sánchez, José | SP | Cleveland Spiders | 26 | 11/27/2008 | Unknown | MEX | Right | Right | 6' 2" | 200 lbs | $510,000 |
| Sánchez, Octávio | SP | Houston Bayou Rats | 25 | 11/27/2009 | Cojutepeque | SLV | Right | Right | 6' 2" | 200 lbs | $11,156,250 |
| Sánchez, Roque | SP | Brooklyn Superbas | 18 | 08/31/2016 | Havana | CUB | Left | Left | 6' 1" | 175 lbs | - |
| Sánchez, Salvador | 1B | Seattle Pilots | 16 | 07/23/2018 | Medellín | COL | Right | Right | 6' 3" | 200 lbs | - |
| Sandoval, Cristo | 2B | Hollywood Stars | 26 | 07/12/2008 | Las Vegas | USA | Right | Right | 6' 1" | 205 lbs | $300,000 |
| Sandoval, Juan | 1B | Seattle Pilots | 24 | 07/10/2010 | Comitan | MEX | Right | Right | 6' 0" | 195 lbs | $300,000 |
| Santana, Jesús | RP | Hollywood Stars | 23 | 03/06/2011 | Guadalajara | MEX | Right | Right | 6' 0" | 190 lbs | - |
| Santingo, Rubén | SP | Brooklyn Superbas | 17 | 06/12/2017 | Bayamo | CUB | Left | Left | 6' 3" | 180 lbs | - |
| Santos, Luis | RP | Rochester Redbirds | 23 | 06/01/2011 | Izúcar | MEX | Right | Right | 5' 11" | 185 lbs | $300,000 |
| Sato, Nobuyori | RP | Seattle Pilots | 26 | 12/13/2008 | Toyama | JPN | Left | Right | 6' 0" | 185 lbs | $300,000 |
| Sato, Suezo | SP | Brooklyn Superbas | 19 | 06/05/2015 | Kakogawa | JPN | Left | Left | 6' 3" | 185 lbs | - |
| Schmidt, Daniel | 3B | Cleveland Spiders | 23 | 12/01/2011 | Round Rock | USA | Right | Right | 6' 0" | 190 lbs | $300,000 |
| Schoon, Tonny | CF | Boston Beaneaters | 25 | 09/22/2009 | Bergen | NED | Right | Right | 6' 2" | 195 lbs | $300,000 |
| Serrano, Norberto | 1B | Brooklyn Superbas | 26 | 09/14/2008 | Culiacan | MEX | Switch | Right | 6' 2" | 230 lbs | $300,000 |
| Seto, Tung | SS | Houston Bayou Rats | 17 | 06/26/2017 | Chungli | TPE | Right | Right | 6' 0" | 175 lbs | - |
| Seymour, Brandon | C | Miami X Giants | 31 | 04/21/2003 | Unknown | USA | Right | Right | 6' 2" | 230 lbs | $300,000 |
| Shang, Pin-zhen | SP | Chicago Whales | 16 | 11/15/2018 | Taichung | TPE | Right | Right | 6' 0" | 170 lbs | - |
| Shao, Shi-yu | 2B | Hollywood Stars | 25 | 03/10/2009 | Jinchengjiang | CHN | Right | Right | 6' 1" | 195 lbs | $300,000 |
| Shaw, John | 2B | Brooklyn Superbas | 24 | 03/22/2010 | Kingwood | USA | Right | Right | 5' 8" | 180 lbs | $300,000 |
| Shaw, Matt | SP | Rochester Redbirds | 29 | 11/19/2005 | Oakland | USA | Switch | Right | 6' 7" | 235 lbs | $12,800,000 |
| Shiraishi, Yoshifumi | 3B | Boston Beaneaters | 31 | 12/17/2003 | Yoshida | JPN | Right | Right | 6' 0" | 210 lbs | $3,480,000 |
| Shiu, Hsin-ta | SP | Oakland Oaks | 35 | 11/19/1999 | Macheng | CHN | Left | Right | 6' 0" | 215 lbs | $12,400,000 |
| Sigua, Alonso | SP | Chicago Whales | 17 | 07/05/2017 | Baracoa | CUB | Switch | Right | 6' 3" | 185 lbs | - |
| Silva, Jesús | SP | Hollywood Stars | 17 | 02/19/2017 | Guantanamo | CUB | Left | Left | 6' 3" | 185 lbs | - |
| Silva, Vincente | 2B | Free Agent | 30 | 02/04/2004 | Norfolk | USA | Left | Right | 6' 0" | 200 lbs | - |
| Simmons, Ronnie | 2B | Oakland Oaks | 24 | 12/18/2010 | Windsor | USA | Left | Right | 6' 0" | 180 lbs | $300,000 |
| Simpson, Josh | 2B | Houston Bayou Rats | 33 | 04/30/2001 | Franklin | USA | Right | Right | 5' 9" | 235 lbs | $9,000,000 |
| Singleton, Brent | RP | Brooklyn Superbas | 33 | 08/13/2001 | Wells Branch | USA | Left | Left | 5' 10" | 235 lbs | $530,000 |
| Sitton, Chris | SP | Oakland Oaks | 34 | 04/04/2000 | New York | USA | Right | Right | 6' 0" | 190 lbs | $12,600,000 |
| Small, Julius | RP | Seattle Pilots | 24 | 06/18/2010 | Washington | USA | Right | Right | 6' 3" | 205 lbs | $300,000 |
| Smith, Clinton | 2B | Free Agent | 29 | 10/02/2005 | Euless | USA | Switch | Right | 6' 1" | 210 lbs | - |
| Snow, Ric | LF | St. Louis Perfectos | 27 | 01/19/2007 | Oceanside | USA | Left | Left | 6' 0" | 210 lbs | $10,800,000 |
| Solís, José | SP | Seattle Pilots | 16 | 04/22/2018 | Bayaguana | DOM | Left | Left | 6' 1" | 175 lbs | - |
| Solís, Luis | SP | Rochester Redbirds | 20 | 12/19/2014 | San Francisco de Macorís | DOM | Left | Left | 6' 3" | 190 lbs | - |
| Sousa, Gustavo | 2B | Cleveland Spiders | 19 | 11/06/2015 | Santo Domingo | DOM | Right | Right | 6' 4" | 195 lbs | - |
| Souza, Carlos | SP | Rochester Redbirds | 16 | 03/03/2018 | Manzanillo | CUB | Right | Right | 6' 2" | 180 lbs | - |
| Stanley, Mason | RP | Free Agent | 28 | 08/09/2006 | Montgomery | USA | Right | Right | 6' 3" | 220 lbs | - |
| Suárez, Charlie | RP | Philadelphia Quakers | 25 | 08/14/2009 | Fort Worth | USA | Right | Right | 6' 3" | 200 lbs | $300,000 |
| Suárez, Luis | C | Seattle Pilots | 18 | 01/10/2017 | Santo Domingo | DOM | Right | Right | 6' 2" | 200 lbs | - |
| Suárez, Tomás | SP | Houston Bayou Rats | 27 | 12/26/2007 | Unknown | DOM | Right | Right | 5' 11" | 185 lbs | $6,250,000 |
| Sullivan, Mike | LF | Oakland Oaks | 29 | 01/31/2005 | Toppenish | USA | Right | Right | 6' 0" | 210 lbs | $1,100,000 |
| Sun, Xiao-gang | 2B | Miami X Giants | 26 | 05/08/2008 | Luchou | TPE | Right | Right | 6' 0" | 195 lbs | $300,000 |
| Suzuki, Norishige | SS | St. Louis Perfectos | 17 | 05/11/2017 | Ageo | JPN | Right | Right | 6' 4" | 185 lbs | - |
